Let's see...
8-Bit Theatre
One of two great sprite comics on the internet, it revolves around the plot of FFI. Since that's non-existent, they just make jokes.
Count Your Sheep
One of the few webcomics which needs no introduction, this is funny as heck.
Dominic Deegan: Oracle For Hire
Lot of puns in a vivid fantasy world. This rocks.
Girly
The prequel to CuteWendy, this updates sprodically but is still good
Its Walky
The comic that got me into webcomicry. Ending...tomorrow
Mac Hall
Another sprodically updating comic, but good art and jokes.
Masters of The Art
A good newcomer to the scene, with some funny setpieces.
Modest Destiny
The other good sprite comic. Or "Pixel Art". Still good despite the "PA" thing, whatever that was.
Real Life Comics
The title is about as apt as Trojan Condoms. Leave any sense of continunity behind, but keep your sense of humour - you'll need it.
Sinfest
Good art and jokes, although the political angle is lost on me.
Wapsi Square
There are two good reasons to read this comic. The jokes, and the cool art.
Whatta think I meant?
Angels 2200
Five girls on a spaceship with nobody for company but a robotic gigolo? Sounds good to me...
Apple Geeks
Good art and jokes, plus
excellent colouring.
El Goonish Shive
More surreal than a Jason Pollack painting, this thing rocks.
MegaTokyo
THE webcomic. Although the story is a bit disjointed, the art rocks the pants off nearly everyone else.
Sore Thumbs
Political jokes aside, this is a good comic.
RPG World
Like Final Fantasy? You'll love this.
Starcross'D Destiny
Exposition and excellent art make this a comic not for the Penny Arcade fan. But everyone else will enjoy it.
SGVY
Transgendered girl fights evil with a giant hammer. Don't ask.